Curated Information
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Curated Information Page
PubMed Id: 10869359 
Guan KL, et al. (2000) Negative regulation of the serine/threonine kinase B-Raf by Akt. J Biol Chem 275, 27354-9 10869359
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S365-p - BRAF (human)
Orthologous residues
BRAF (human): S365‑p, BRAF (mouse): S348‑p, BRAF iso3 (mouse): S298‑p, BRAF (rat): S347‑p, BRAF (chicken): S365‑p, BRAF (quail): S365‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited

S429-p - BRAF (human)
Orthologous residues
BRAF (human): S429‑p, BRAF (mouse): S464‑p, BRAF iso3 (mouse): S362‑p, BRAF (rat): S463‑p, BRAF (chicken): S469‑p, BRAF (quail): S469‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Akt1 (human)
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited

T440-p - BRAF (human)
Orthologous residues
BRAF (human): T440‑p, BRAF (mouse): T477‑p, BRAF iso3 (mouse): , BRAF (rat): T477‑p, BRAF (chicken): T480‑p, BRAF (quail): T480‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited


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