Curated Information
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Curated Information Page
PubMed Id: 21115493 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
He KL, et al. (2011) Feedback regulation of endothelial cell surface plasmin generation by PKC-dependent phosphorylation of annexin A2. J Biol Chem 286, 15428-39 21115493
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S12-p - ANXA2 (human) ▲
Orthologous residues
ANXA2 (human): S12‑p, ANXA2 (mouse): S12‑p, ANXA2 (rat): S12‑p, ANXA2 (dog): S12‑p, ANXA2 (cow): S12‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), HUVEC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) siRNA inhibition of enzyme, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
plasmin increase
siRNA plasmin inhibit treatment-induced increase siRNA PKCA
siRNA plasmin TLR4 (human) inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
S100A10 (human) Disrupts protein degradation co-immunoprecipitation

S26-p - ANXA2 (human) ▲
Orthologous residues
ANXA2 (human): S26‑p, ANXA2 (mouse): S26‑p, ANXA2 (rat): S26‑p, ANXA2 (dog): S26‑p, ANXA2 (cow): S26‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial), HUVEC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) siRNA inhibition of enzyme, activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
plasmin increase
siRNA plasmin inhibit treatment-induced increase siRNA PKCA
siRNA plasmin TLR4 (human) inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  intracellular localization, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
S100A10 (human) Disrupts protein degradation co-immunoprecipitation


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