|
Orthologous residues
|
|
RYR2 (human): S2814‑p, RYR2 (mouse): S2813‑p, RYR2 (rat): S2804‑p, RYR2 (rabbit): S2815‑p, RYR2 (dog): S2799‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody, western blotting
|
|
Relevant cell lines - cell types - tissues:
heart
|
|
Cellular systems studied:
tissue
|
|
Species studied:
mouse
|
|
Enzymes shown to modify site in vitro:
|
|
|
|
Upstream Regulation
|
|
Potential in vivo enzymes for site:
|
|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
CaMK2-alpha (mouse)
|
pharmacological inhibitor of upstream enzyme
|
|
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
KN-93
|
|
|
|
decrease
|
|
|
|
Downstream Regulation
|
|
Effect of modification (function):
activation
|
|
Associated Diseases
|
|
Diseases:
|
Alterations:
|
Comments:
|
|
ventricular tachycardia
|
increased
|
|
|
