Curated Information

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Curated Information Page

PubMed Id: 11920685

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Tobiume K, Saitoh M, Ichijo H (2002) Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer. J Cell Physiol 191, 95-104 11920685

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T845-p - ASK1 (mouse)

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Orthologous residues

ASK1 (human): T838‑p, ASK1 iso5 (human): T918‑p, ASK1 (mouse): T845‑p, ASK1 (rat): T809‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 293 (epithelial), MEF (fibroblast) [IGF1R (mouse)]

Cellular systems studied: cell lines

Species studied: human, mouse

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	ASK1 (mouse)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	ASK1 (mouse)	transfection of inactive enzyme

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
H2O2				increase

T849-p - ASK1 (mouse)

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Orthologous residues

ASK1 (human): T842‑p, ASK1 iso5 (human): T922‑p, ASK1 (mouse): T849‑p, ASK1 (rat): T813‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody

Relevant cell lines - cell types - tissues: 293 (epithelial)

Cellular systems studied: cell lines

Species studied: human

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