Curated Information
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Curated Information Page
PubMed Id: 12086603 
Taniguchi T, et al. (2002) Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell 109, 459-72 12086603
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S222-p - FANCD2 (human)
Orthologous residues
FANCD2 (human): S222‑p, FANCD2 (mouse): S220‑p, FANCD2 (rat): S222‑p, FANCD2 (chicken): S225‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  ataxia-telangiectasia
 Relevant cell lines - cell types - tissues:  AT22IJE-T (fibroblast), FA-D2 (fibroblast), GM01526 (fibroblast), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  PD7 lymphoblasts, PD20F
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATM (human)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
ionizing radiation no change compared to control ATM-deficient AT cells
Downstream Regulation
 Effect of modification (process):  cell cycle regulation
 Comments:  Phosphorylation of FANCD2 on S222 is required for the IR-inducible S phase checkpoint but not the G1/S or G2/M checkpoints

S1404-p - FANCD2 (human)
Orthologous residues
FANCD2 (human): S1404‑p, FANCD2 (mouse): S1404‑p, FANCD2 (rat): S1406‑p, FANCD2 (chicken):
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  ataxia-telangiectasia
 Relevant cell lines - cell types - tissues:  AT22IJE-T (fibroblast), FA-D2 (fibroblast), GM01526 (fibroblast), HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
 Comments:  PD7 lymphoblasts, PD20F
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ionizing radiation increase
ionizing radiation no change compared to control ATM-deficient AT cells


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