Curated Information

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Curated Information Page

PubMed Id: 11934902

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Cheriyath V, Desgranges ZP, Roy AL (2002) c-Src-dependent transcriptional activation of TFII-I. J Biol Chem 277, 22798-805 11934902

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

Y248-p - GTF2I iso2 (human)

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Orthologous residues

GTF2I (human): Y248‑p, GTF2I iso2 (human): Y248‑p, GTF2I (mouse): Y248‑p, GTF2I iso8 (mouse): Y248‑p, GTF2I (rat): Y248‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 3T3 (fibroblast), COS (fibroblast), SYF (fibroblast)

Cellular systems studied: cell lines

Species studied: monkey, mouse

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	Src (human)	pharmacological activator of upstream enzyme, transfection of wild-type enzyme, pharmacological inhibitor of upstream enzyme, modification site within consensus motif, genetic transfer of dominant-negative enzyme, genetic knockout/knockin of upstream enzyme, phospho-antibody

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
EGF				increase
PP2	EGF			inhibit treatment-induced increase

Downstream Regulation

Effect of modification (function): activation

Effect of modification (process): transcription, altered

Y611-p - GTF2I iso2 (human)

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