Curated Information
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PubMed Id: 11934902 
Cheriyath V, Desgranges ZP, Roy AL (2002) c-Src-dependent transcriptional activation of TFII-I. J Biol Chem 277, 22798-805 11934902
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y248-p - GTF2I iso2 (human)
Orthologous residues
GTF2I (human): Y248‑p, GTF2I iso2 (human): Y248‑p, GTF2I (mouse): Y248‑p, GTF2I iso8 (mouse): Y248‑p, GTF2I (rat): Y248‑p, GTF2I iso2 (rat):
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), COS (fibroblast), SYF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) phospho-antibody, genetic knockout/knockin of upstream enzyme, transfection of wild-type enzyme, pharmacological inhibitor of upstream enzyme, modification site within consensus motif, pharmacological activator of upstream enzyme, genetic transfer of dominant-negative enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
PP2 EGF inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  transcription, induced

Y611-p - GTF2I iso2 (human)
Orthologous residues
GTF2I (human): Y652‑p, GTF2I iso2 (human): Y611‑p, GTF2I (mouse): Y652‑p, GTF2I iso8 (mouse): Y612‑p, GTF2I (rat): Y633‑p, GTF2I iso2 (rat): Y567‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), COS (fibroblast), SYF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) phospho-motif antibody, transfection of wild-type enzyme, pharmacological activator of upstream enzyme, genetic transfer of dominant-negative enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
 Effect of modification (process):  transcription, induced


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