Curated Information
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Curated Information Page
PubMed Id: 11934902 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Cheriyath V, Desgranges ZP, Roy AL (2002) c-Src-dependent transcriptional activation of TFII-I. J Biol Chem 277, 22798-805 11934902
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y248-p - GTF2I iso2 (human)
Orthologous residues
GTF2I (human): Y248‑p, GTF2I iso2 (human): Y248‑p, GTF2I (mouse): Y248‑p, GTF2I iso8 (mouse): Y248‑p, GTF2I (rat): Y248‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), COS (fibroblast), SYF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of wild-type enzyme, modification site within consensus motif, pharmacological activator of upstream enzyme, phospho-antibody, genetic transfer of dominant-negative enzyme, pharmacological inhibitor of upstream enzyme, genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
PP2 EGF inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  transcription, induced

Y611-p - GTF2I iso2 (human)
Orthologous residues
GTF2I (human): Y652‑p, GTF2I iso2 (human): Y611‑p, GTF2I (mouse): Y652‑p, GTF2I iso8 (mouse): Y612‑p, GTF2I (rat): Y633‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast), COS (fibroblast), SYF (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  monkey, mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of wild-type enzyme, pharmacological activator of upstream enzyme, phospho-motif antibody, genetic transfer of dominant-negative enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EGF increase
Downstream Regulation
 Effect of modification (process):  transcription, induced


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