Curated Information

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Curated Information Page

PubMed Id: 12000743

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Wang Z, Frederick J, Garabedian MJ (2002) Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo. J Biol Chem 277, 26573-80 12000743

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S203-p - GR (human)

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Orthologous residues

GR (human): S203‑p, GR iso2 (human): S203‑p, GR (mouse): S212‑p, GR (rat): S224‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Disease tissue studied: bone cancer, lung cancer

Relevant cell lines - cell types - tissues: A549 (pulmonary), liver, lymph node, prostate, thyroid, U2OS (bone cell) [GR (human)]

Cellular systems studied: cell lines, tissue

Species studied: human

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Effect
dexamethasone		increase
RU-486		increase
prednisolone		increase
fluocinolone		increase
ZK299		no change compared to control
RU-486	dexamethasone	no effect upon treatment-induced increase
ZK299	dexamethasone	no effect upon treatment-induced increase

S211-p - GR (human)

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