Curated Information
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Curated Information Page
PubMed Id: 18086859 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Shinohara H, Maeda S, Watarai H, Kurosaki T (2007) IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells. J Exp Med 204, 3285-93 18086859
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T119-p - CARD11 (chicken) ▲
Orthologous residues
CARD11 (human): T117‑p, CARD11 (mouse): T117‑p, CARD11 (chicken): T119‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase

S578-p - CARD11 (chicken) ▲
Orthologous residues
CARD11 (human): S562‑p, CARD11 (mouse): S567‑p, CARD11 (chicken): S578‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE IKK-beta (rat) genetic knockout/knockin of upstream enzyme, transfection of inactive enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Bcl-10 (human) Induces co-immunoprecipitation
MALT1 (human) Induces co-immunoprecipitation

S668-p - CARD11 (chicken) ▲
Orthologous residues
CARD11 (human): S652‑p, CARD11 (mouse): S657‑p, CARD11 (chicken): S668‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody
 Disease tissue studied:  lymphoma, B cell lymphoma
 Relevant cell lines - cell types - tissues:  DT40 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  chicken
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE PKCB (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCB (human) genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Bcl-10 (human) Induces co-immunoprecipitation
MALT1 (human) Induces co-immunoprecipitation


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