Curated Information
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Curated Information Page
PubMed Id: 18070928 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
de Graauw M, et al. (2008) Annexin A2 phosphorylation mediates cell scattering and branching morphogenesis via cofilin Activation. Mol Cell Biol 28, 1029-40 18070928
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S3-p - cofilin 1 (human) ▲
Orthologous residues
cofilin 1 (human): S3‑p, cofilin 1 (mouse): S3‑p, cofilin 1 (rat): S3‑p, cofilin 1 (pig): S3‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LIMK1 (human) transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (process):  cell motility, altered, cytoskeletal reorganization
 Comments:  regulates F-actin organization and dynamics; involved in the ROCK/LIMK-dependent dephosphorylation/activation of cofilin

Y24-p - ANXA2 (dog) ▲
Orthologous residues
ANXA2 (human): Y24‑p, ANXA2 (mouse): Y24‑p, ANXA2 (rat): Y24‑p, ANXA2 (dog): Y24‑p, ANXA2 (cow): Y24‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site
 Relevant cell lines - cell types - tissues:  MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (process):  cell motility, altered, cytoskeletal reorganization
 Comments:  regulates F-actin organization and dynamics; involved in the ROCK/LIMK-dependent dephosphorylation/activation of cofilin


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