Curated Information
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Curated Information Page
PubMed Id: 18070928 
de Graauw M, et al. (2008) Annexin A2 phosphorylation mediates cell scattering and branching morphogenesis via cofilin Activation. Mol Cell Biol 28, 1029-40 18070928
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S3-p - Cofilin-1 (human)
Orthologous residues
Cofilin‑1 (human): S3‑p, Cofilin‑1 (mouse): S3‑p, Cofilin‑1 (rat): S3‑p, Cofilin‑1 (pig): S3‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE LIMK1 (human) transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (process):  cell motility, altered, cytoskeletal reorganization
 Comments:  regulates F-actin organization and dynamics; involved in the ROCK/LIMK-dependent dephosphorylation/activation of cofilin

Y24-p - ANXA2 (dog)
Orthologous residues
ANXA2 (human): Y24‑p, ANXA2 (mouse): Y24‑p, ANXA2 (rat): Y24‑p, ANXA2 (dog): Y24‑p, ANXA2 (cow): Y24‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  MDCK (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  dog
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Src (human) transfection of constitutively active enzyme
Downstream Regulation
 Effect of modification (process):  cell motility, altered, cytoskeletal reorganization
 Comments:  regulates F-actin organization and dynamics; involved in the ROCK/LIMK-dependent dephosphorylation/activation of cofilin


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