Curated Information
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Curated Information Page
PubMed Id: 18070880 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Piao W, et al. (2008) Tyrosine Phosphorylation of MyD88 Adapter-like (Mal) Is Critical for Signal Transduction and Blocked in Endotoxin Tolerance. J Biol Chem 283, 3109-19 18070880
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y86-p - TIRAP (human) ▲
Orthologous residues
TIRAP (human): Y86‑p, TIRAP (mouse): Y106‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, phosphorylation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Btk (human) Induces co-immunoprecipitation
MYD88 (human) Disrupts co-immunoprecipitation
TLR4 (human) Disrupts co-immunoprecipitation

Y106-p - TIRAP (human) ▲
Orthologous residues
TIRAP (human): Y106‑p, TIRAP (mouse): Y126‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, phosphorylation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TLR4 (human) Disrupts co-immunoprecipitation
MYD88 (human) Disrupts co-immunoprecipitation
Btk (human) Induces co-immunoprecipitation

Y187-p - TIRAP (human) ▲
Orthologous residues
TIRAP (human): Y187‑p, TIRAP (mouse): Y207‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  molecular association, regulation, phosphorylation
 Effect of modification (process):  transcription, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
TLR4 (human) Disrupts co-immunoprecipitation
Btk (human) Induces co-immunoprecipitation
MYD88 (human) Disrupts co-immunoprecipitation


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