Curated Information
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Curated Information Page
PubMed Id: 10698938 
Zheng XM, Resnick RJ, Shalloway D (2000) A phosphotyrosine displacement mechanism for activation of Src by PTPalpha. EMBO J 19, 964-78 10698938
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y789-p - PTPRA iso2 (human)
Orthologous residues
PTPRA (human): Y798‑p, PTPRA iso2 (human): Y789‑p, PTPRA (mouse): Y825‑p, PTPRA (rat): Y792‑p
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast) [SHP-2 (mouse), homozygous knockout]
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
EDTA decrease
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Src (chicken) Induces activity, induced in vitro, functional assay, co-immunoprecipitation
 Comments:  PTP-alpha binding to Src via Y527 allows dephosphorylation of this residue.

Y527-p - Src (chicken)
Orthologous residues
Src (human): Y530‑p, Src iso2 (human): Y536‑p, Src (mouse): Y535‑p, Src iso2 (mouse): Y529‑p, Src (rat): Y530‑p, Src (chicken): Y527‑p
 Enzymes shown to modify site in vitro
Type Enzyme

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