Curated Information
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Curated Information Page
PubMed Id: 11923305 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Zheng XM, Resnick RJ, Shalloway D (2002) Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation. J Biol Chem 277, 21922-9 11923305
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S180-p - PTPRA iso2 (human) ▲
Orthologous residues
PTPRA (human): S189‑p, PTPRA iso2 (human): S180‑p, PTPRA (mouse): S180‑p, PTPRA (rat): S183‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, electrophoretic mobility shift, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation, phosphorylation
 Effect of modification (process):  cell growth, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Grb2 (human) SH2 Disrupts co-immunoprecipitation
Src (human) SH2 Induces enzymatic activity, induced co-immunoprecipitation
 Comments:  promotes PTPRA tyrosine phosphorylation

S204-p - PTPRA iso2 (human) ▲
Orthologous residues
PTPRA (human): S213‑p, PTPRA iso2 (human): S204‑p, PTPRA (mouse): S204‑p, PTPRA (rat): S207‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, electrophoretic mobility shift, mutation of modification site, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  3T3 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation, phosphorylation
 Effect of modification (process):  cell growth, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Src (human) SH2 Induces enzymatic activity, induced co-immunoprecipitation
Grb2 (human) SH2 Disrupts co-immunoprecipitation
 Comments:  promotes PTPRA tyrosine phosphorylation


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