Curated Information
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Curated Information Page
PubMed Id: 10469656 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Thomson S, et al. (1999) The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase. EMBO J 18, 4779-93 10469656
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S11-p - H3 iso3 (mouse)
Orthologous residues
H3 (human): S11‑p, H3 (mouse): S11‑p, H3 iso2 (mouse): S11‑p, H3 iso3 (mouse): S11‑p, H3 (rat): S11‑p, H3 iso3 (rat): S11‑p, H3 (pig): S11‑p, H3 (chicken): S11‑p, H3 (cow): S11‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  C3H10T1/2 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE RSK2 (mouse)
KINASE MSK1 (mouse)
KINASE p90RSK (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
PD98059 phorbol ester inhibit treatment-induced increase
H-89 phorbol ester inhibit treatment-induced increase
anisomycin increase
SB203580 anisomycin inhibit treatment-induced increase
H-89 anisomycin inhibit treatment-induced increase
EGF increase
H-89 EGF inhibit treatment-induced increase

S7-p - HMGN1 (mouse)
Orthologous residues
HMGN1 (human): S7‑p, HMGN1 (mouse): S7‑p, HMGN1 (rat): S7‑p, HMGN1 (cow): S7‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  C3H10T1/2 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE MSK1 (mouse)
KINASE RSK2 (mouse)
KINASE p90RSK (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
PD98059 phorbol ester inhibit treatment-induced increase
H-89 phorbol ester inhibit treatment-induced increase
anisomycin increase
SB203580 anisomycin inhibit treatment-induced increase
H-89 anisomycin inhibit treatment-induced increase
EGF increase
H-89 EGF inhibit treatment-induced increase


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