Curated Information
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Curated Information Page
PubMed Id: 9405465 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Mammen AL, Kameyama K, Roche KW, Huganir RL (1997) Phosphorylation of the alpha-amino-3-hydroxy-5-methylisoxazole4-propionic acid receptor GluR1 subunit by calcium/calmodulin-dependent kinase II. J Biol Chem 272, 32528-33 9405465
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S849-p - GluR1 (rat)
Orthologous residues
GluR1 (human): S849‑p, GluR1 (mouse): S849‑p, GluR1 (rat): S849‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  'brain, hippocampus', 293 (epithelial), QT-6 (fibroblast) [CAMK2A (human)], QT-6 (fibroblast) [GluR1 (rat)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, quail, rat
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CAMK2A (rat)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CAMK2A (rat) pharmacological activator of upstream enzyme, pharmacological inhibitor of upstream enzyme, transfection of constitutively active enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
KN-62 decrease
A23187 increase
KN-62 A23187 inhibit treatment-induced increase

S863-p - GluR1 (rat)
Orthologous residues
GluR1 (human): S863‑p, GluR1 (mouse): S863‑p, GluR1 (rat): S863‑p
Characterization
 Methods used to characterize site in vivo 2D analysis, [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  'brain, hippocampus', 293 (epithelial), QT-6 (fibroblast) [GluR1 (rat)]
 Cellular systems studied:  cell lines, primary cells
 Species studied:  human, quail, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
forskolin increase
IBMX, forskolin increase


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