Curated Information
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Curated Information Page
PubMed Id: 11909947 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Kabak S, et al. (2002) The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways. Mol Cell Biol 22, 2524-35 11909947
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y176-p - Ig-alpha (mouse)
Orthologous residues
Ig‑alpha (human): Y182‑p, Ig‑alpha (mouse): Y176‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, peptide sequencing
 Disease tissue studied:  lymphoma, B cell lymphoma
 Cellular systems studied:  cell lines
 Species studied:  mouse

Y182-p - Ig-alpha (mouse)
Orthologous residues
Ig‑alpha (human): Y188‑p, Ig‑alpha (mouse): Y182‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, peptide sequencing
 Disease tissue studied:  lymphoma, B cell lymphoma
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
Downstream Regulation
 Effect of modification (function):  phosphorylation

Y193-p - Ig-alpha (mouse)
Orthologous residues
Ig‑alpha (human): Y199‑p, Ig‑alpha (mouse): Y193‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, peptide sequencing
 Disease tissue studied:  lymphoma, B cell lymphoma
 Cellular systems studied:  cell lines
 Species studied:  mouse
Downstream Regulation
 Effect of modification (function):  phosphorylation

Y204-p - Ig-alpha (mouse)
Orthologous residues
Ig‑alpha (human): Y210‑p, Ig‑alpha (mouse): Y204‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry, mutation of modification site, peptide sequencing
 Disease tissue studied:  lymphoma, B cell lymphoma
 Cellular systems studied:  cell lines
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BLNK (mouse) SH2 Induces phosphorylation pull-down assay


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