Curated Information

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PubMed Id: 11238922

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Hall C, et al. (2001) HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression. Mol Cell Biol 21, 1854-65 11238922

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T555-p - HIRA (human)

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Orthologous residues

HIRA (human): T555‑p, HIRA (mouse): T554‑p, HIRA (rat): T554‑p

Characterization

Methods used to characterize site in vivo: mass spectrometry, mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: U2OS (bone cell) [GR (human)]

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	CDK2 (human)

Upstream Regulation

Potential in vivo enzymes for site:

Type	Enzyme	Evidence	Notes
KINASE	CDK2 (human)	inhibition of upstream enzyme, phospho-antibody

S687-p - HIRA (human)

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Orthologous residues

HIRA (human): S687‑p, HIRA (mouse): G685‑p, HIRA (rat): G685‑p

Characterization

Methods used to characterize site in vivo: mass spectrometry

Relevant cell lines - cell types - tissues: U2OS (bone cell) [GR (human)]

Cellular systems studied: cell lines

Species studied: human

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