Curated Information
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Curated Information Page
PubMed Id: 11279195 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Lutz W, et al. (2001) Phosphorylation of centrin during the cell cycle and its role in centriole separation preceding centrosome duplication. J Biol Chem 276, 20774-80 11279195
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S170-p - CETN2 (human)
Orthologous residues
CETN2 (human): S170‑p, CETN2 (mouse): S170‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human, quail
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (cow)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (cow) pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cAMP analog increase
IBMX, cAMP analog cAMP analog augment treatment-induced increase
Downstream Regulation
 Effect of modification (process):  cell cycle regulation


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