Curated Information
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Curated Information Page
PubMed Id: 9636152 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Information from this record has been curated, but not yet edited in PhosphoSitePlus® and may be incomplete.
Malek SN, et al. (1998) Malignant transformation of early lymphoid progenitors in mice expressing an activated Blk tyrosine kinase. Proc Natl Acad Sci U S A 95, 7351-6 9636152
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Y495-p - BLK (mouse)
Orthologous residues
BLK (human): Y501‑p, BLK (mouse): Y495‑p, BLK (rat): Y495‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, western blotting
 Relevant cell lines - cell types - tissues:  B lymphocyte [BLK (mouse), transgenic], T lymphocyte-thymus [BIK (mouse), transgenic]
 Cellular systems studied:  cell lines
 Species studied:  mouse
 Comments:  constitutively active mutant Y495F
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited
 Effect of modification (process):  cell growth, altered
 Comments:  Constitutively active mutant developed lymphomas. Tyrosine phosphorylated proteins such as PLC-gamma and PI3K, were seen in tumors.


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