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Orthologous residues
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Blk (human): Y501‑p, Blk (mouse): Y495‑p, Blk (rat): Y495‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site, western blotting
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Relevant cell lines - cell types - tissues:
B lymphocyte [Blk (mouse), transgenic], T lymphocyte-thymus [Bik (mouse), transgenic]
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Cellular systems studied:
cell lines
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Species studied:
mouse
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Comments:
constitutively active mutant Y495F
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Downstream Regulation
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Effect of modification (function):
enzymatic activity, inhibited
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Effect of modification (process):
cell growth, altered
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Comments:
Constitutively active mutant developed lymphomas. Tyrosine phosphorylated proteins such as PLC-gamma and PI3K, were seen in tumors.
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