Curated Information
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Curated Information Page
PubMed Id: 10559944 
Saxena M, Williams S, Taskén K, Mustelin T (1999) Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase. Nat Cell Biol 1, 305-11 10559944
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S44-p - HePTP (human)
Orthologous residues
HePTP (human): S44‑p, HePTP iso3 (human): S149‑p, HePTP iso4 (human): S118‑p, HePTP (mouse): S44‑p, HePTP (rat): S44‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKACA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (human) pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
cAMP analog increase
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
ERK2 (human) Disrupts activity, induced co-immunoprecipitation

S93-p - HePTP (human)
Orthologous residues
HePTP (human): S93‑p, HePTP iso3 (human): S198‑p, HePTP iso4 (human): S167‑p, HePTP (mouse): S93‑p, HePTP (rat): S93‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, phosphoamino acid analysis
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human


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