Curated Information
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Curated Information Page
PubMed Id: 9312162 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Heyeck SD, Wilcox HM, Bunnell SC, Berg LJ (1997) Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. J Biol Chem 272, 25401-8 9312162
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Y512-p - ITK (human)
Orthologous residues
ITK (human): Y512‑p, ITK (mouse): Y517‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, peptide sequencing, phospho-antibody, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte) [ITK (human)], Jurkat (T lymphocyte) [Lck (human)], SF9 [ITK (human)], SF9 [Lck (human)]
 Cellular systems studied:  cell lines
 Species studied:  human, insect
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Lck (human) genetic transfer of dominant-negative enzyme, genetic transfer of wild-type enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-CD3 increase
Downstream Regulation
 Effect of modification (function):  activity, induced


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