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Orthologous residues
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|
RRas (human): Y66‑p, RRas (mouse): Y66‑p
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Characterization
|
|
Methods used to characterize site in vivo:
mutation of modification site, phospho-antibody, western blotting
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|
Relevant cell lines - cell types - tissues:
293T (epithelial), MDCK (epithelial)
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|
Cellular systems studied:
cell lines
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|
Species studied:
dog, human
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Upstream Regulation
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|
Potential in vivo enzymes for site:
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|
Type
|
Enzyme
|
Evidence
|
Notes
|
|
KINASE
|
Src (human)
|
transfection of inactive enzyme, co-immunoprecipitation, phospho-motif antibody, transfection of constitutively active enzyme, genetic transfer of inducible upstream enzyme, genetic transfer of constitutively active upstream enzyme
|
|
|
|
Downstream Regulation
|
|
Effect of modification (process):
cell adhesion, altered
|
