Curated Information
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PubMed Id: 10908600 
Paul S, et al. (2000) The Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway. J Neurosci 20, 5630-8 10908600
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S49-p - STEP (rat)
Orthologous residues
STEP (human): S245‑p, STEP (mouse): S221‑p, STEP (rat): S49‑p
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, phosphoamino acid analysis, phosphopeptide mapping
 Relevant cell lines - cell types - tissues:  'brain, striatum'
 Cellular systems studied:  tissue
 Species studied:  rat
 Enzymes shown to modify site in vitro
Type Enzyme
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKACA (rat) phospho-antibody, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
SKF81297 increase
H-89 SKF81297 inhibit treatment-induced increase
dopamine SKF81297 augment treatment-induced increase
SCH 23390 SKF81297 inhibit treatment-induced increase
dopamine increase
quinpirole dopamine no effect upon treatment-induced increase
SCH 23390 dopamine inhibit treatment-induced increase
H-89 no change compared to control

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