Curated Information
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Curated Information Page
PubMed Id: 20940393 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wang H, et al. (2010) Phosphorylation of RalB is important for bladder cancer cell growth and metastasis. Cancer Res 70, 8760-9 20940393
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S198-p - RalB (human)
Orthologous residues
RalB (human): S198‑p, RalB (mouse): S198‑p, RalB (rat): S198‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  bladder cancer
 Relevant cell lines - cell types - tissues:  293T (epithelial), RT112, UMUC3 (bladder cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PKCA (human) pharmacological inhibitor of upstream enzyme, pharmacological activator of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
Go 6983 phorbol ester inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  carcinogenesis, altered, cell growth, altered, cell motility, altered, cytoskeletal reorganization
 Comments:  necessary for the development of experimental lung metastasis of human bladder cancer cells


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