Palacios D, et al. (2010) TNF/p38α/polycomb signaling to Pax7 locus in satellite cells links inflammation to the epigenetic control of muscle regeneration. Cell Stem Cell 7, 455-69 20887952

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T367-p - EZH2 (human) ▲

Modsite: NNssRPstPtINVLE SwissProt Entrez-Gene Orthologous residues EZH2 (human): T367‑p, EZH2 iso2 (human): T372‑p, EZH2 (mouse): T367‑p, EZH2 (rat): T367‑p Characterization Methods used to characterize site in vivo:  [32P] ATP in vitro, immunoprecipitation, mutation of modification site, western blotting Relevant cell lines - cell types - tissues:  C2C12 (myoblast), muscle cell Cellular systems studied:  cell lines Species studied:  mouse Enzymes shown to modify site in vitro:  Type Enzyme KINASE P38A (human) Upstream Regulation Potential in vivo enzymes for site:  Type Enzyme Evidence Notes KINASE P38A (human) pharmacological inhibitor of upstream enzyme, activation of upstream enzyme, phospho-antibody Treatments, proteins and their effect on site modification:  Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes MKK6 (human) increase SB203580 decrease EZH2 (human) increase EZH2 siRNA decrease Downstream Regulation Effect of modification (function):  molecular association, regulation Effect of modification (process):  cell differentiation, induced, cell growth, inhibited, transcription, inhibited Modification regulates interactions with:  Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays YY1 (human) Induces co-immunoprecipitation