Curated Information
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Curated Information Page
PubMed Id: 20937773 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Matthess Y, et al. (2010) Cdk1/cyclin B1 controls Fas-mediated apoptosis by regulating caspase-8 activity. Mol Cell Biol 30, 5726-40 20937773
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S387-p - CASP8 (human)
Orthologous residues
CASP8 (human): S387‑p, CASP8 iso4 (human): S404‑p, CASP8 iso9 (human): S446‑p, CASP8 (mouse): S390‑p, CASP8 (rat): S391‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  breast cancer, colorectal cancer, colorectal carcinoma
 Relevant cell lines - cell types - tissues:  breast, HCT116 (intestinal), HeLa (cervical), MDA-MB231 (breast cell), SKW 6.4 (B lymphocyte), SW480 (intestinal), T47D (breast cell)
 Cellular systems studied:  cell lines, tissue
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CDK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK1 (human) pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nocodazole increase
RO-3306 nocodazole inhibit treatment-induced increase
CCNB1 (human) increase
nocodazole FasL (human) inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, intracellular localization, protein processing
 Effect of modification (process):  apoptosis, altered, carcinogenesis, altered
Associated Diseases
Diseases: Alterations: Comments:
breast ductal carcinoma increased


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