Curated Information
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Curated Information Page
PubMed Id: 20724523 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Garcia-Haro L, et al. (2010) The PP1-R6 protein phosphatase holoenzyme is involved in the glucose-induced dephosphorylation and inactivation of AMP-activated protein kinase, a key regulator of insulin secretion, in MIN6 beta cells. FASEB J 24, 5080-91 20724523
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S428-p - LKB1 (human)
Orthologous residues
LKB1 (human): S428‑p, LKB1 iso2 (human): , LKB1 (mouse): S431‑p, LKB1 (rat): S431‑p, LKB1 (pig): S339‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
 Relevant cell lines - cell types - tissues:  MIN6 (pancreatic)
 Cellular systems studied:  cell lines
 Species studied:  human

T183-p - AMPKA1 (mouse)
Orthologous residues
AMPKA1 (human): T183‑p, AMPKA1 (mouse): T183‑p, AMPKA1 (rat): T183‑p, AMPKA1 (fruit fly): T184‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Disease tissue studied:  pancreatic cancer, pancreatic carcinoma
 Relevant cell lines - cell types - tissues:  MIN6 (pancreatic)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE PPP1CA (human)
PHOSPHATASE PPP2CA (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PPP1CB (mouse) phospho-antibody, siRNA inhibition of enzyme in complex with the PPP1R3D (R6) regulatory subunit
PHOSPHATASE PPP1CA (mouse) phospho-antibody, siRNA inhibition of enzyme in complex with the PPP1R3D (R6) regulatory subunit
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
glucose GK (mouse) decrease
glucose PPP1R3D (mouse) GK (mouse) inhibit treatment-induced decrease
glucose PPP1R3E (mouse) GK (mouse) inhibit treatment-induced decrease
glucose PPP1R3C (human) GK (mouse) no effect upon treatment-induced decrease
fructose no change compared to control
galactose no change compared to control
2-deoxyglucose no change compared to control


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