Curated Information
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Curated Information Page
PubMed Id: 20593489 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Sun L, et al. (2010) Tumour suppressor CYLD is a negative regulator of the mitotic kinase Aurora-B. J Pathol 221, 425-32 20593489
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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T232-p - AurB (human)
Orthologous residues
AurB (human): T232‑p, AurB (mouse): T237‑p, AurB (rat): T235‑p, AurB (pig): T232‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PPP2CA (human) co-immunoprecipitation, phospho-antibody, transfection of wild-type enzyme CYLD interacts with PPP2CA and modulates dephosphorylation.
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CYLD (human) decrease siRNA increases; overexpression decreases

S7-p - CENPA (human)
Orthologous residues
CENPA (human): S7‑p, CENPA (mouse): , CENPA (rat):
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CYLD (human) decrease siRNA increases; overexpression decreases
PPP2CA (human) decrease
CYLD (human) PPP2CA (human) augment treatment-induced decrease siRNA inhibits decrease

S11-p - H3 (human)
Orthologous residues
H3 (human): S11‑p, H3 (mouse): S11‑p, H3 iso2 (mouse): S11‑p, H3 iso3 (mouse): S11‑p, H3 (rat): S11‑p, H3 iso3 (rat): S11‑p, H3 (pig): S11‑p, H3 (chicken): S11‑p, H3 (cow): S11‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  HeLa (cervical)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
CYLD (human) decrease siRNA increases; overexpression decreases
PPP2CA (human) decrease
CYLD (human) PPP2CA (human) augment treatment-induced decrease siRNA inhibits decrease


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