Curated Information
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Curated Information Page
PubMed Id: 19525936 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Peng G, et al. (2009) BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol 11, 865-72 19525936
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S969-p - SMARCC2 (human)
Orthologous residues
SMARCC2 (human): S969‑p, SMARCC2 iso2 (human): S1000‑p, SMARCC2 (mouse): S969‑p, SMARCC2 (rat): S1000‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  293T (epithelial), U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ATR (human)
KINASE ATM (human)
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Effect of modification (process):  chromatin organization, altered
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
MCPH1 (human) Induces co-immunoprecipitation
 Comments:  interaction enhanced after DNA damage with ionizing radiation


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