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Orthologous residues
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SMARCC2 (human): S969‑p, SMARCC2 iso2 (human): S1000‑p, SMARCC2 (mouse): S969‑p, SMARCC2 (rat): S1005‑p
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Characterization
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Methods used to characterize site in vivo:
immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
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Disease tissue studied:
bone cancer
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Relevant cell lines - cell types - tissues:
293T (epithelial), U2OS (bone cell)
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Cellular systems studied:
cell lines
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Species studied:
human
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Enzymes shown to modify site in vitro:
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Downstream Regulation
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Effect of modification (function):
molecular association, regulation
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Effect of modification (process):
chromatin organization, altered
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Modification regulates interactions with:
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Interacting molecule
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Interacting domains
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Effect
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Consequences (function)
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Consequences (process)
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Detection assays
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MCPH1 (human)
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Induces
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|
|
co-immunoprecipitation
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Comments:
interaction enhanced after DNA damage with ionizing radiation
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