Curated Information
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Curated Information Page
PubMed Id: 20702409 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Bledzka K, et al. (2010) Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation. J Biol Chem 285, 30370-4 20702409
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y783-p - ITGB1 (human)
Orthologous residues
ITGB1 (human): Y783‑p, ITGB1 iso2 (human): , ITGB1 iso3 (human): , ITGB1 iso5 (human): Y783‑p, ITGB1 (mouse): Y783‑p, ITGB1 iso5 (mouse): Y783‑p, ITGB1 (rat): Y784‑p, ITGB1 (chicken): Y788‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO-K1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster

Y795-p - ITGB1 (human)
Orthologous residues
ITGB1 (human): Y795‑p, ITGB1 iso2 (human): , ITGB1 iso3 (human): , ITGB1 iso5 (human): Y795‑p, ITGB1 (mouse): Y795‑p, ITGB1 iso5 (mouse): Y795‑p, ITGB1 (rat): Y796‑p, ITGB1 (chicken): Y800‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO-K1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Kindlin-2 (human) Disrupts pull-down assay, in vitro

Y773-p - ITGB3 (human)
Orthologous residues
ITGB3 (human): Y773‑p, ITGB3 (mouse): Y772‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO-K1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster

Y785-p - ITGB3 (human)
Orthologous residues
ITGB3 (human): Y785‑p, ITGB3 (mouse): Y784‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  CHO-K1 (fibroblast)
 Cellular systems studied:  cell lines
 Species studied:  hamster
Downstream Regulation
 Effect of modification (function):  activity, inhibited, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
Kindlin-2 (human) Disrupts activity, inhibited plasmon resonance, co-immunoprecipitation


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