Curated Information
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Curated Information Page
PubMed Id: 20711186 
Deng JV, et al. (2010) MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants. Nat Neurosci 13, 1128-36 20711186
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S421-p - MECP2 (mouse)
Orthologous residues
MECP2 (human): S423‑p, MECP2 iso2 (human): S435‑p, MECP2 (mouse): S421‑p, MECP2 iso2 (mouse): S438‑p, MECP2 (rat): S421‑p
 Methods used to characterize site in vivo phospho-antibody
 Relevant cell lines - cell types - tissues:  'brain, nucleus accumbens'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
amphetamine increase
SCH 23390 amphetamine inhibit treatment-induced increase
SKF81297 increase
Downstream Regulation
 Comments:  correlated with behavioral sensitization to amphetamine

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