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Orthologous residues
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ataxin‑1 (human): S775‑p, ataxin‑1 (mouse): S751‑p, ataxin‑1 (rat): S749‑p
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Characterization
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Methods used to characterize site in vivo:
mutation of modification site
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Relevant cell lines - cell types - tissues:
'neuron, Purkinje'-'brain, cerebellum'
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Cellular systems studied:
primary cells
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Species studied:
mouse
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Comments:
transgenic mice expressing ATXN1[82Q]-D752
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Downstream Regulation
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Effect of modification (process):
apoptosis, altered
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Comments:
S776D mutation initiates neuronal death
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