Curated Information
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Curated Information Page
PubMed Id: 20564182 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Motiwala T, et al. (2010) Lyn kinase and ZAP70 are substrates of PTPROt in B-cells: Lyn inactivation by PTPROt sensitizes leukemia cells to VEGF-R inhibitor pazopanib. J Cell Biochem 110, 846-56 20564182
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y397-p - Lyn (human)
Orthologous residues
Lyn (human): Y397‑p, Lyn iso2 (human): Y376‑p, Lyn (mouse): Y397‑p, Lyn iso2 (mouse): Y376‑p, Lyn (rat): Y397‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PTPRO (human) transfection of inactive enzyme, transfection of wild-type enzyme Y397 is strongly dephosphorylated while Y507 is weakly dephosphorylated
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced
 Effect of modification (process):  cell growth, altered

Y508-p - Lyn (human)
Orthologous residues
Lyn (human): Y508‑p, Lyn iso2 (human): Y487‑p, Lyn (mouse): Y508‑p, Lyn iso2 (mouse): Y487‑p, Lyn (rat): Y508‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293T (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE PTPRO (human) transfection of inactive enzyme, transfection of wild-type enzyme Y397 is strongly dephosphorylated while Y507 is weakly dephosphorylated


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