Curated Information
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Curated Information Page
PubMed Id: 20689073 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Wang J, et al. (2010) Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 30, 1976-82 20689073
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y284-p - GIT1 (human)
Orthologous residues
GIT1 (human): Y284‑p, GIT1 iso3 (human): Y297‑p, GIT1 (mouse): Y293‑p, GIT1 (rat): Y293‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), A7r5 ('muscle, smooth')
 Cellular systems studied:  cell lines
 Species studied:  human, rat

Y321-p - GIT1 (human)
Orthologous residues
GIT1 (human): Y321‑p, GIT1 iso3 (human): Y334‑p, GIT1 (mouse): Y330‑p, GIT1 (rat): Y330‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), A7r5 ('muscle, smooth')
 Cellular systems studied:  cell lines
 Species studied:  human, rat

Y383-p - GIT1 (human)
Orthologous residues
GIT1 (human): Y383‑p, GIT1 iso3 (human): Y396‑p, GIT1 (mouse): Y392‑p, GIT1 (rat): Y392‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  293 (epithelial), A7r5 ('muscle, smooth')
 Cellular systems studied:  cell lines
 Species studied:  human, rat
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
phorbol ester increase
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell motility, altered, cytoskeletal reorganization
 Comments:  important for podosome formation and PLC gamma activation


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