Curated Information
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Curated Information Page
PubMed Id: 20697431 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Shi G, Yue G, Zhou R (2010) EphA3 functions are regulated by collaborating phosphotyrosine residues. Cell Res 20, 1263-75 20697431
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y596-p - EphA3 (mouse) ▲
Orthologous residues
EphA3 (human): Y596‑p, EphA3 (mouse): Y596‑p, EphA3 (rat): Y597‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal', 293A (epithelial), NG108-15 (neuron)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, rat
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE EphA3 (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ephrin A5 increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced

Y602-p - EphA3 (mouse) ▲
Orthologous residues
EphA3 (human): Y602‑p, EphA3 (mouse): Y602‑p, EphA3 (rat): Y603‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal', 293A (epithelial), NG108-15 (neuron)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, rat
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE EphA3 (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ephrin A5 increase
Downstream Regulation
 Effect of modification (process):  carcinogenesis, altered, cell motility, altered

Y779-p - EphA3 (mouse) ▲
Orthologous residues
EphA3 (human): Y779‑p, EphA3 (mouse): Y779‑p, EphA3 (rat): Y780‑p
Characterization
 Methods used to characterize site in vivo:  mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  neuroblastoma
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal', 293A (epithelial), NG108-15 (neuron)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, rat
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE EphA3 (mouse)
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
ephrin A5 increase
Downstream Regulation
 Effect of modification (process):  carcinogenesis, altered, cell motility, altered


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