Curated Information

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Curated Information Page

PubMed Id: 20724593

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Lin L, et al. (2010) tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway. Am J Pathol 177, 1687-96 20724593

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S9-p - GSK3B (mouse)

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Orthologous residues

GSK3B (human): S9‑p, GSK3B iso2 (human): S9‑p, GSK3B (mouse): S9‑p, GSK3B (rat): S9‑p, GSK3B (rabbit): S3‑p

Characterization

Methods used to characterize site in vivo: immunoprecipitation, mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: PEA-13 (fibroblast)

Cellular systems studied: cell lines

Species studied: mouse

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
tPA				increase

Downstream Regulation

Effect of modification (function): enzymatic activity, inhibited

Y4508-p - LRP1 (mouse)

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