Curated Information
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Curated Information Page
PubMed Id: 20730378 
Hunter C, et al. (2010) Selective inhibitors of Kv11.1 regulate IL-6 expression by macrophages in response to TLR/IL-1R ligands. ScientificWorldJournal 10, 1580-96 20730378
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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S76-p - C/EBP-beta (human)
Orthologous residues
C/EBP‑beta (human): S76‑p, C/EBP‑beta (mouse): S64‑p, C/EBP‑beta (rat): S64‑p, C/EBP‑beta (chicken): S65‑p
 Methods used to characterize site in vivo mutation of modification site, phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  P388 ('B lymphocyte, precursor')
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CDK2 (mouse) pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
LPS increase
dofetilide LPS inhibit treatment-induced increase
Downstream Regulation
 Effect of modification (process):  transcription, induced

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