Curated Information
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Curated Information Page
PubMed Id: 20739275 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Kassel KM, et al. (2010) Regulation of human cytidine triphosphate synthetase 2 by phosphorylation. J Biol Chem 285, 33727-36 20739275
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S564-p - CTPS2 (human) ▲
Orthologous residues
CTPS2 (human): S564‑p, CTPS2 (mouse): S564‑p, CTPS2 (rat): S564‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y567-p - CTPS2 (human) ▲
Orthologous residues
CTPS2 (human): Y567‑p, CTPS2 (mouse): Y567‑p, CTPS2 (rat): Y567‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

S568-p - CTPS2 (human) ▲
Orthologous residues
CTPS2 (human): S568‑p, CTPS2 (mouse): S568‑p, CTPS2 (rat): S568‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE CK1-A (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK1-A (human) pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IC261 decrease
serum withdrawal increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited

S571-p - CTPS2 (human) ▲
Orthologous residues
CTPS2 (human): S571‑p, CTPS2 (mouse): S571‑p, CTPS2 (rat): S571‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IC261 decrease
serum withdrawal increase

S574-p - CTPS2 (human) ▲
Orthologous residues
CTPS2 (human): S574‑p, CTPS2 (mouse): S574‑p, CTPS2 (rat): S574‑p
Characterization
 Methods used to characterize site in vivo:  [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human


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