Curated Information
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Curated Information Page
PubMed Id: 20739275 
Kassel KM, et al. (2010) Regulation of human cytidine triphosphate synthetase 2 by phosphorylation. J Biol Chem 285, 33727-36 20739275
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S564-p - CTPS2 (human)
Orthologous residues
CTPS2 (human): S564‑p, CTPS2 (mouse): S564‑p, CTPS2 (rat): S564‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

Y567-p - CTPS2 (human)
Orthologous residues
CTPS2 (human): Y567‑p, CTPS2 (mouse): Y567‑p, CTPS2 (rat): Y567‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human

S568-p - CTPS2 (human)
Orthologous residues
CTPS2 (human): S568‑p, CTPS2 (mouse): S568‑p, CTPS2 (rat): S568‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1A (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE CK1A (human) pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IC261 decrease
serum withdrawal increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited

S571-p - CTPS2 (human)
Orthologous residues
CTPS2 (human): S571‑p, CTPS2 (mouse): S571‑p, CTPS2 (rat): S571‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
IC261 decrease
serum withdrawal increase

S574-p - CTPS2 (human)
Orthologous residues
CTPS2 (human): S574‑p, CTPS2 (mouse): S574‑p, CTPS2 (rat): S574‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mass spectrometry, mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human


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