Curated Information
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Curated Information Page
PubMed Id: 20305697 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Xu Y, et al. (2010) Role of CK1 in GSK3beta-mediated phosphorylation and degradation of snail. Oncogene 29, 3124-33 20305697
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S96-p - Snail1 (human)
Orthologous residues
Snail1 (human): S96‑p, Snail1 (mouse): S96‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
 Comments:  prior phosphorylation of S104 and S107 by CK1 allows GSK3B phosphorylation of S96 and S100

S100-p - Snail1 (human)
Orthologous residues
Snail1 (human): S100‑p, Snail1 (mouse): S100‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE GSK3B (human)
 Comments:  prior phosphorylation of S104 and S107 by CK1 allows GSK3B phosphorylation of S96 and S100

S104-p - Snail1 (human)
Orthologous residues
Snail1 (human): S104‑p, Snail1 (mouse): S104‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1E (human)
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Comments:  in vitro

S107-p - Snail1 (human)
Orthologous residues
Snail1 (human): S107‑p, Snail1 (mouse): S107‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE CK1E (human)
Downstream Regulation
 Effect of modification (function):  protein degradation, ubiquitination
 Comments:  in vitro


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