|
Orthologous residues
|
|
p70S6K (human): T412‑p, p70S6K iso2 (human): T389‑p, p70S6K (mouse): T412‑p, p70S6K (rat): T412‑p, p70S6K iso2 (rat): T389‑p, p70S6K (fruit fly): T398‑p
|
|
Characterization
|
|
Methods used to characterize site in vivo:
phospho-antibody, western blotting
|
|
Relevant cell lines - cell types - tissues:
embryonic
|
|
Cellular systems studied:
primary cells
|
|
Species studied:
mouse
|
|
Comments:
blastocysts
|
|
Upstream Regulation
|
|
Treatments, proteins and their effect on site modification:
|
|
Treatments
|
Referenced Treatments
|
Manipulated Protein
|
Referenced Protein
|
Effect
|
Notes
|
|
serum
|
|
|
|
increase
|
|
|
|
serum
|
PSEN1 (mouse)
|
|
no effect upon treatment-induced increase
|
no effect of PSEN1 knockout
|
|
serum withdrawal
|
|
|
|
decrease
|
|
|
|
serum withdrawal
|
PSEN1 (mouse)
|
|
no effect upon treatment-induced decrease
|
no effect of PSEN1 knockout
|
|
