Curated Information
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Curated Information Page
PubMed Id: 20434984 
Rahl PB, et al. (2010) c-Myc regulates transcriptional pause release. Cell 141, 432-45 20434984
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1616-p - POLR2A (human)
Orthologous residues
POLR2A (human): S1616‑p, POLR2A var1 (human): S1616‑p, POLR2A (mouse): S1616‑p, POLR2A (rat): S1616‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Disease tissue studied:  lung cancer, mesothelioma
 Relevant cell lines - cell types - tissues:  MES (pulmonary)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
flavopiridol decrease
10058-F4 decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  transcription, induced
 Comments:  S1619-P was detected in promoter region of active genes, while S1616-P was detected downstream of polyadenylation site.

S1619-p - POLR2A (human)
Orthologous residues
POLR2A (human): S1619‑p, POLR2A var1 (human): S1619‑p, POLR2A (mouse): S1619‑p, POLR2A (rat): S1619‑p
Characterization
 Methods used to characterize site in vivo immunoprecipitation, phospho-antibody, western blotting
 Disease tissue studied:  lung cancer, mesothelioma
 Relevant cell lines - cell types - tissues:  MES (pulmonary)
 Cellular systems studied:  cell lines
 Species studied:  human
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
10058-F4 no change compared to control
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  transcription, induced
 Comments:  S1619-P was detected in promoter region of active genes, while S1616-P was detected downstream of polyadenylation site.


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