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PubMed Id: 20616029

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Chau MD, et al. (2010) Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. Proc Natl Acad Sci U S A 107, 12553-8 20616029

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

T183-p - AMPKA1 (human)

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Orthologous residues

AMPKA1 (human): T183‑p, AMPKA1 (mouse): T183‑p, AMPKA1 (rat): T183‑p, AMPKA1 (fruit fly): T184‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: adipocyte

Cellular systems studied: primary cultured cells

Species studied: human

Comments: differentiated preadipocytes

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
FGF21				increase

S79-p - ACC1 (mouse)

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Orthologous residues

ACC1 (human): S80‑p, ACC1 iso4 (human): S117‑p, ACC1 (mouse): S79‑p, ACC1 (rat): S79‑p, ACC1 iso2 (rat): S79‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 3T3-L1 (fibroblast), adipose tissue

Cellular systems studied: cell lines, tissue

Species studied: mouse

Comments: 3T3-L1 differentiated into adipocytes

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
FGF21				increase

T183-p - AMPKA1 (mouse)

▲

Orthologous residues

AMPKA1 (human): T183‑p, AMPKA1 (mouse): T183‑p, AMPKA1 (rat): T183‑p, AMPKA1 (fruit fly): T184‑p

Characterization

Methods used to characterize site in vivo: phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: 3T3-L1 (fibroblast), adipose tissue

Cellular systems studied: cell lines, tissue

Species studied: mouse

Comments: 3T3-L1 differentiated into adipocytes

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
FGF21				increase

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