Curated Information
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Curated Information Page
PubMed Id: 20661443 
Sylvester M, et al. (2010) Adhesion and degranulation promoting adapter protein (ADAP) is a central hub for phosphotyrosine-mediated interactions in T cells. PLoS One 5, e11708 20661443
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y559-p - SLAP-130 (human)
Orthologous residues
SLAP‑130 (human): Y559‑p, SLAP‑130 iso2 (human): Y559‑p, SLAP‑130 (mouse): Y547‑p, SLAP‑130 (rat): Y548‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)
Downstream Regulation
 Effect of modification (process):  cell adhesion, altered, cell motility, altered
 Comments:  promotes adhesion to fibronectin; promotes cell migration

Y571-p - SLAP-130 (human)
Orthologous residues
SLAP‑130 (human): Y571‑p, SLAP‑130 iso2 (human): Y571‑p, SLAP‑130 (mouse): Y559‑p, SLAP‑130 (rat): Y560‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)
Downstream Regulation
 Effect of modification (process):  cell motility, altered
 Comments:  promotes cell migration

Y595-p - SLAP-130 (human)
Orthologous residues
SLAP‑130 (human): Y595‑p, SLAP‑130 iso2 (human): Y595‑p, SLAP‑130 (mouse): Y584‑p, SLAP‑130 (rat): Y585‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)
Downstream Regulation
 Effect of modification (process):  cell adhesion, altered, cell motility, altered
 Comments:  promotes adhesion to ICAM-1; promotes cell migration

Y651-p - SLAP-130 (human)
Orthologous residues
SLAP‑130 (human): Y651‑p, SLAP‑130 iso2 (human): Y697‑p, SLAP‑130 (mouse): Y687‑p, SLAP‑130 (rat): Y688‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)
Downstream Regulation
 Effect of modification (process):  cell adhesion, altered, cell motility, altered
 Comments:  promotes adhesion to ICAM-1; promotes cell migration

Y755-p - SLAP-130 (human)
Orthologous residues
SLAP‑130 (human): Y755‑p, SLAP‑130 iso2 (human): Y801‑p, SLAP‑130 (mouse): Y791‑p, SLAP‑130 (rat): Y792‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)
Downstream Regulation
 Effect of modification (process):  cell adhesion, altered, cell motility, altered
 Comments:  promotes adhesion to ICAM-1; promotes cell migration

Y757-p - SLAP-130 (human)
Orthologous residues
SLAP‑130 (human): Y757‑p, SLAP‑130 iso2 (human): Y803‑p, SLAP‑130 (mouse): Y793‑p, SLAP‑130 (rat): Y794‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)

Y771-p - SLAP-130 (human)
Orthologous residues
SLAP‑130 (human): Y771‑p, SLAP‑130 iso2 (human): Y817‑p, SLAP‑130 (mouse): Y807‑p, SLAP‑130 (rat): Y808‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)
Downstream Regulation
 Effect of modification (process):  cell adhesion, altered, cell motility, altered
 Comments:  promotes adhesion to ICAM-1; promotes cell migration

Y780-p - SLAP-130 (human)
Orthologous residues
SLAP‑130 (human): Y780‑p, SLAP‑130 iso2 (human): Y826‑p, SLAP‑130 (mouse): Y816‑p, SLAP‑130 (rat): Y817‑p
Characterization
 Methods used to characterize site in vivo mass spectrometry (in vitro), mutation of modification site
 Relevant cell lines - cell types - tissues:  Jurkat (T lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE Fyn (human)
Downstream Regulation
 Effect of modification (process):  cell adhesion, altered
 Comments:  promotes adhesion to ICAM-1


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