Curated Information
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Curated Information Page
PubMed Id: 20457598 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Egloff S, et al. (2010) The integrator complex recognizes a new double mark on the RNA polymerase II carboxyl-terminal domain. J Biol Chem 285, 20564-9 20457598
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S1616-p - POLR2A (human) ▲
Orthologous residues
POLR2A (human): S1616‑p, POLR2A var1 (human): S1616‑p, POLR2A (mouse): S1616‑p, POLR2A (rat): S1616‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE DNAPK (human)
 Comments:  kinase activity higher on S1621 than S1616
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
INTS11 (human) Induces pull-down assay, in vitro

S1619-p - POLR2A (human) ▲
Orthologous residues
POLR2A (human): S1619‑p, POLR2A var1 (human): S1619‑p, POLR2A (mouse): S1619‑p, POLR2A (rat): S1619‑p

S1621-p - POLR2A (human) ▲
Orthologous residues
POLR2A (human): S1621‑p, POLR2A var1 (human): S1621‑p, POLR2A (mouse): S1621‑p, POLR2A (rat): S1621‑p
Characterization
 Enzymes shown to modify site in vitro: 
Type Enzyme
KINASE DNAPK (human)
 Comments:  kinase activity higher on S1621 than S1616
Downstream Regulation
 Effect of modification (function):  molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
INTS11 (human) Induces pull-down assay, in vitro


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