Curated Information
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Curated Information Page
PubMed Id: 20577264 
Liu XS, Li H, Song B, Liu X (2010) Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery. EMBO Rep 11, 626-32 20577264
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S223-p - GTSE1 (human)
Orthologous residues
GTSE1 (human): S223‑p, GTSE1 (mouse): , GTSE1 (rat):
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PLK1 (human)

S435-p - GTSE1 (human)
Orthologous residues
GTSE1 (human): S435‑p, GTSE1 (mouse): S434‑p, GTSE1 (rat): S442‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  293T (epithelial), U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PLK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK1 (human) pharmacological inhibitor of upstream enzyme, siRNA inhibition of enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nocodazole increase
siRNA nocodazole inhibit treatment-induced increase Plk1 siRNA
BI2536 decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell cycle regulation
 Comments:  important for p53 inactivation during G2 checkpoint recovery


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