Curated Information
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Curated Information Page
PubMed Id: 20577264 
Liu XS, Li H, Song B, Liu X (2010) Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery. EMBO Rep 11, 626-32 20577264
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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S223-p - GTSE1 (human)
Orthologous residues
GTSE1 (human): S223‑p, GTSE1 (mouse): , GTSE1 (rat):
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PLK1 (human)

S435-p - GTSE1 (human)
Orthologous residues
GTSE1 (human): S435‑p, GTSE1 (mouse): S434‑p, GTSE1 (rat): S442‑p
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, mutation of modification site, phospho-antibody, western blotting
 Disease tissue studied:  bone cancer
 Relevant cell lines - cell types - tissues:  293T (epithelial), U2OS (bone cell)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PLK1 (human)
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE PLK1 (human) siRNA inhibition of enzyme, pharmacological inhibitor of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
nocodazole increase
siRNA nocodazole inhibit treatment-induced increase Plk1 siRNA
BI2536 decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
 Effect of modification (process):  cell cycle regulation
 Comments:  important for p53 inactivation during G2 checkpoint recovery

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