Curated Information
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Curated Information Page
PubMed Id: 11514608 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Tsuji S, et al. (2001) B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1. J Exp Med 194, 529-39 11514608
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Y379-p - HPK1 (mouse)
Orthologous residues
HPK1 (human): Y381‑p, HPK1 (mouse): Y379‑p
Characterization
 Methods used to characterize site in vivo [32P] bio-synthetic labeling, immunoprecipitation, mutation of modification site, phospho-antibody
 Relevant cell lines - cell types - tissues:  B lymphocyte-spleen, COS (fibroblast), WEHI-231 (B lymphocyte)
 Cellular systems studied:  cell lines
 Species studied:  human, monkey
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
KINASE Syk (mouse) genetic transfer of wild-type enzyme, genetic knockout/knockin of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
anti-IgM increase
Downstream Regulation
 Effect of modification (function):  enzymatic activity, induced, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
BLNK (mouse) Induces activity, induced electrophoretic visualization, co-immunoprecipitation


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