Curated Information
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Curated Information Page
PubMed Id: 20530479 
Gasser A, et al. (2010) Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK. J Biol Chem 285, 26149-61 20530479
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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S553-p - SCN8A (mouse)
Orthologous residues
SCN8A (human): S553‑p, SCN8A (mouse): S553‑p, SCN8A (rat): S553‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE P38A (human)
Downstream Regulation
 Effect of modification (function):  activity, inhibited, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NEDD4L (human) Induces pull-down assay

Y1945-p - SCN8A (mouse)
Orthologous residues
SCN8A (human): Y1947‑p, SCN8A (mouse): Y1945‑p, SCN8A (rat): Y1945‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  'neuron, hippocampal, CA1 pyramidal', 293 (epithelial)
 Cellular systems studied:  cell lines, primary cultured cells
 Species studied:  human, mouse
Downstream Regulation
 Effect of modification (function):  activity, inhibited, molecular association, regulation
 Modification regulates interactions with: 
Interacting molecule Interacting domains Effect Consequences (function) Consequences (process) Detection assays
NEDD4L (human) Induces pull-down assay


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