Curated Information

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Curated Information Page

PubMed Id: 20530479

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Gasser A, et al. (2010) Two Nedd4-binding motifs underlie modulation of sodium channel Nav1.6 by p38 MAPK. J Biol Chem 285, 26149-61 20530479

Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.

S553-p - SCN8A (mouse)

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Orthologous residues

SCN8A (human): S553‑p, SCN8A (mouse): S553‑p, SCN8A (rat): S553‑p

Characterization

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	P38A (human)

Downstream Regulation

Effect of modification (function): inhibition, molecular association, regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
NEDD4L (human)		Induces			pull-down assay

Y1945-p - SCN8A (mouse)

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Orthologous residues

SCN8A (human): Y1947‑p, SCN8A (mouse): Y1945‑p, SCN8A (rat): Y1945‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site

Relevant cell lines - cell types - tissues: 'neuron, hippocampal, CA1 pyramidal', 293 (epithelial)

Cellular systems studied: cell lines, primary cultured cells

Species studied: human, mouse

Downstream Regulation

Effect of modification (function): inhibition, molecular association, regulation

Modification regulates interactions with:

Interacting molecule	Interacting domains	Effect	Consequences (function)	Consequences (process)	Detection assays
NEDD4L (human)		Induces			pull-down assay

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