Curated Information
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PubMed Id: 20427654 
Kurup P, et al. (2010) Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. J Neurosci 30, 5948-57 20427654
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Click on the protein name to open the protein page, and on the RSD number to open the site page.
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Y1474-p - NMDAR2B (human)
Orthologous residues
NMDAR2B (human): Y1474‑p, NMDAR2B (mouse): Y1472‑p, NMDAR2B (rat): Y1472‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE STEP (human)

S245-p - STEP (human)
Orthologous residues
STEP (human): S245‑p, STEP (mouse): S221‑p, STEP (rat): S49‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited

Y1472-p - NMDAR2B (mouse)
Orthologous residues
NMDAR2B (human): Y1474‑p, NMDAR2B (mouse): Y1472‑p, NMDAR2B (rat): Y1472‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE STEP (mouse) activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
beta-amyloid decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease decreased result of increased levels and activity of STEP phosphatase in aged Tg2576 mice

S49-p - STEP (rat)
Orthologous residues
STEP (human): S245‑p, STEP (mouse): S221‑p, STEP (rat): S49‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
beta-amyloid decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, ubiquitination


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