Curated Information
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Curated Information Page
PubMed Id: 20427654 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Kurup P, et al. (2010) Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. J Neurosci 30, 5948-57 20427654
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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Y1474-p - NMDAR2B (human)
Orthologous residues
NMDAR2B (human): Y1474‑p, NMDAR2B (mouse): Y1472‑p, NMDAR2B (rat): Y1472‑p
Characterization
 Enzymes shown to modify site in vitro
Type Enzyme
PHOSPHATASE STEP (human)

S245-p - STEP (human)
Orthologous residues
STEP (human): S245‑p, STEP (mouse): S221‑p, STEP (rat): S49‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  293 (epithelial)
 Cellular systems studied:  cell lines
 Species studied:  human
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited

Y1472-p - NMDAR2B (mouse)
Orthologous residues
NMDAR2B (human): Y1474‑p, NMDAR2B (mouse): Y1472‑p, NMDAR2B (rat): Y1472‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Potential in vivo enzymes for site: 
Type Enzyme Evidence Notes
PHOSPHATASE STEP (mouse) activation of upstream enzyme
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
beta-amyloid decrease
Downstream Regulation
 Effect of modification (function):  intracellular localization
Associated Diseases
Diseases: Alterations: Comments:
Alzheimer's disease decreased result of increased levels and activity of STEP phosphatase in aged Tg2576 mice

S49-p - STEP (rat)
Orthologous residues
STEP (human): S245‑p, STEP (mouse): S221‑p, STEP (rat): S49‑p
Characterization
 Methods used to characterize site in vivo phospho-antibody, western blotting
 Relevant cell lines - cell types - tissues:  'brain, cerebral cortex'
 Cellular systems studied:  tissue
 Species studied:  mouse
Upstream Regulation
 Treatments, proteins and their effect on site modification: 
Treatments Referenced Treatments Manipulated Protein Referenced Protein Effect Notes
beta-amyloid decrease
Downstream Regulation
 Effect of modification (function):  enzymatic activity, inhibited, ubiquitination


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