Curated Information
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Curated Information Page
PubMed Id: 15938644 
Donella-Deana A, et al. (2005) Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity. Biochemistry 44, 8533-42 15938644
This page summarizes selected information from the record referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
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Y1278-p - ALK (human)
Orthologous residues
ALK (human): Y1278‑p, ALK (mouse): Y1282‑p
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE ALK (human)
 Comments:  The substrate is a 21-mer peptide whose sequence whose sequence corresponds to the A-loop of human Alk: ARDIY*RASYYRKGGCAMLPVK. The homologous peptide from the InsR, in which the phosphoacceptor site is followed by the amino acids ETD instead of RAS, is not readily phosphorylated by ALK unless the "ETD" triplet is changed to "RAS". Ile and Arg at n-1 and n+6 also contribute to the efficient phosphorylation by ALK.

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