Curated Information

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Curated Information Page

PubMed Id: 11463380

This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus^®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus^®, click here.

Zanger K, Radovick S, Wondisford FE (2001) CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box. Mol Cell 7, 551-8 11463380

S436-p - CBP (mouse)

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Orthologous residues

CBP (human): S437‑p, CBP (mouse): S436‑p, CBP (rat): S436‑p

Characterization

Methods used to characterize site in vivo: mutation of modification site, phospho-antibody, western blotting

Relevant cell lines - cell types - tissues: HepG2 (hepatic)

Cellular systems studied: cell lines

Species studied: human

Enzymes shown to modify site in vitro:

Type	Enzyme
KINASE	PKCA (mouse)

Upstream Regulation

Treatments, proteins and their effect on site modification:

Treatments	Referenced Treatments	Manipulated Protein	Referenced Protein	Effect	Notes
EGF				increase
insulin				increase

Downstream Regulation

Effect of modification (process): transcription, altered

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