Curated Information
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Curated Information Page
PubMed Id: 20538799 
This page summarizes selected information from the article referenced above and curated into PhosphoSitePlus®, a comprehensive online resource for the study of protein post-translational modifications (NAR, 2012,40:D261-70). To learn more about the scope of PhosphoSitePlus®, click here.
Nigro P, et al. (2010) PKCzeta decreases eNOS protein stability via inhibitory phosphorylation of ERK5. Blood 116, 1971-9 20538799
Only sites from this record are displayed on this page. Click on the protein name to open the protein page, and on the RSD number to open the site page. For the complete dataset, click the download button, on the right.
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K6-sm - ERK5 (mouse)
Orthologous residues
ERK5 (human): K6‑sm, ERK5 (mouse): K6‑sm, ERK5 (rat): K6‑sm
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human

K22-sm - ERK5 (mouse)
Orthologous residues
ERK5 (human): K22‑sm, ERK5 (mouse): K22‑sm, ERK5 (rat): K22‑sm
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human

S486-p - ERK5 (mouse)
Orthologous residues
ERK5 (human): S486‑p, ERK5 (mouse): S486‑p, ERK5 (rat): S486‑p
Characterization
 Methods used to characterize site in vivo mutation of modification site
 Relevant cell lines - cell types - tissues:  HUVEC (endothelial)
 Cellular systems studied:  cell lines
 Species studied:  human
 Enzymes shown to modify site in vitro
Type Enzyme
KINASE PKCZ (human)
Downstream Regulation
 Comments:  TNF-alpha mediated eNOS destabilization


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